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Target intelligence / Profile preview
Human Papillomavirus Type 11 L1 Capsid Protein (HPV-11 L1)
- Target
- HPV-11 L1
- Molecular classification
- Viral structural protein, Capsid protein
01
Overview
The L1 protein is the major capsid protein of human papillomavirus type 11 (HPV-11), a small, non-enveloped, double-stranded DNA virus. It is essential for forming the viral capsid and plays a central role in the assembly of virus-like particles (VLPs) used in HPV vaccines. The L1 protein self-assembles into pentameric structures (capsomeres) which then form an icosahedral capsid. The C-terminal region contains a DNA-binding domain. VLPs composed of recombinant HPV type 11 L1 induce strong type-specific immune responses. The use of HPV vaccines has proven to be highly effective in preventing HPV infections and associated diseases.
- Other names
- HPV11 L1 proteinL1 capsid protein HPV-11HPV-11 major capsid protein
02
Mechanism of action
The L1 protein is the primary antigen used in HPV vaccines. VLPs formed by L1 stimulate a strong neutralizing antibody response, preventing viral infection.
03
Biological functions
Capsid formationGenome encapsulationViral assemblyInduction of neutralizing antibodiesDNA binding
04
Disease associations
InfectionGenital warts (associated with HPV-11)Prophylaxis of HPV-11 infection
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