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Target intelligence / Profile preview
Human Papillomavirus Type 11 L1 Protein (HPV11 L1)
- Target
- HPV11 L1
- Molecular classification
- Viral structural protein, Capsid protein
01
Overview
The major capsid protein L1 from Human Papillomavirus Type 11 (HPV-11) is a key component in prophylactic HPV vaccines. L1 self-assembles into virus-like particles (VLPs) that mimic the native virion structure but lack viral DNA, rendering them non-infectious. These VLPs are highly immunogenic, inducing strong type-specific neutralizing antibody responses that prevent HPV-11 infection. Vaccines containing HPV-11 L1 VLPs, such as Gardasil and Gardasil 9, are used to protect against diseases caused by HPV types including genital warts and respiratory papillomatosis. Recombinant HPV11 L1 is produced primarily in *Saccharomyces cerevisiae*.
- Other names
- HPV-11 L1Human Papillomavirus 11 L1 Major Capsid ProteinHPV11 Major Capsid Protein L1
02
Mechanism of action
Stimulation of neutralizing antibody production via virus-like particle presentation.
03
Biological functions
Virion assemblyCapsid formationImmune response inductionAntigen presentation
04
Disease associations
InfectionGenital wartsRespiratory papillomatosis
05
Interacting drugs
Gardasil
1 more in the full profile.
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