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Target intelligence / Profile preview
Human papillomavirus type 16 (HPV16)
- Target
- HPV16
- Molecular classification
- Virus, DNA virus
01
Overview
HPV16 is a small double-stranded DNA virus that infects mucosal epithelial cells via specific cell surface receptors. It causes a significant proportion of anogenital and head-and-neck cancers worldwide due to its potent oncogenic proteins E6/E7 that disrupt normal cell cycle control mechanisms. Vaccination remains the most effective preventive measure against diseases caused by this virus.
02
Mechanism of action
Vaccines stimulate an immune response to prevent infection.
03
Biological functions
InfectionReplicationOncogenesis
04
Disease associations
CancerInfection
05
Safety considerations
Vaccine side effects (mild, temporary)Potential for vaccine failure in individuals already infected
06
Interacting drugs
Vaccines (HPV vaccines)
07
Biomarkers
HPV16 DNA detection in cervical samplesE6/E7 mRNA expression
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