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Target intelligence / Profile preview
Human Papillomavirus Type 16 E6 Oncoprotein (E6)
- Target
- E6
- Molecular classification
- Oncoprotein
01
Overview
The E6 oncoprotein from human papillomavirus type 16 (HPV16) is a viral protein that plays a central role in the development and maintenance of HPV-associated cancers, particularly cervical cancer. It induces cellular transformation and immortalization by promoting degradation of tumor suppressor p53 and interfering with its transcriptional activity. E6 also activates telomerase, inhibits apoptosis, and modulates immune responses, contributing to oncogenesis. Disruption of E6 function is a promising therapeutic strategy.
02
Mechanism of action
Inhibition of E6/E6AP interaction; Restoration of p53 function
03
Biological functions
Cellular transformationImmortalizationp53 degradationTranscriptional repressionApoptosis inhibitionImmune modulationCell proliferationTelomerase activation
04
Disease associations
CancerCervical cancerHead-and-neck tumorsHPV-associated diseases
05
Safety considerations
Potential for off-target effects due to interactions with multiple host proteinsDevelopment of resistance to E6 inhibitors
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