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Target intelligence / Profile preview
Human Papillomavirus Type 16 E7 Oncoprotein (HPV16 E7)
- Target
- HPV16 E7
- Molecular classification
- Oncoprotein, Viral protein
01
Overview
The E7 oncoprotein is an early gene product of human papillomavirus type 16 (HPV16), a high-risk HPV type strongly associated with cervical and other anogenital cancers. E7, along with the E6 protein, is considered one of the primary drivers of HPV-mediated oncogenesis. E7 plays a critical role in viral genome replication by forcing quiescent host cells to re-enter the cell cycle, stimulating progression from G1 to S phase and disrupting normal cell cycle regulation through binding and inactivation of RB family proteins. It also contributes to immune evasion and genomic instability.
- Other names
- E7 transforming proteinE7 protein
02
Mechanism of action
Disassembly of the E2F1 transcription factor from retinoblastoma protein (RB1), interference with host histone deacetylation via HDAC1/HDAC2 inhibition, inhibition of antiviral and antiproliferative functions mediated by interferon alpha
03
Biological functions
Cell cycle regulationTranscriptional activationInhibition of tumor suppressor pathwaysImmune evasionViral genome replicationInterferon alpha inhibition
04
Disease associations
CancerCervical cancerAnogenital cancers
05
Safety considerations
Targeting E7 must be carefully considered due to its role in cell cycle regulation and potential off-target effects on normal cells.Immune-related adverse events associated with therapeutic vaccines targeting E7.
06
Biomarkers
HPV16 E7 expression (as a marker for HPV-driven cancers)
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