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Human Papillomavirus Type 16 L1 Protein
- Molecular classification
- Viral structural protein, Capsid protein
01
Overview
The L1 protein is the major capsid protein of Human papillomavirus type 16 (HPV16), which is the most oncogenic HPV genotype and a primary cause of cervical, anal, and head and neck cancers. It forms the structural shell of the virus particle (virion) and plays a critical role in viral infectivity, immune recognition, and vaccine development. L1-based VLPs are used as antigens in licensed prophylactic vaccines against oncogenic HPVs due to their ability to induce strong neutralizing antibody responses without containing infectious material.
- Other names
- Major capsid protein L1HPV16 L1
02
Mechanism of action
L1-based VLPs induce neutralizing antibody responses.
03
Biological functions
Virion assemblyHost cell attachmentEndocytosisGenome encapsulationImmune recognition
04
Disease associations
CancerInfection
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