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Target intelligence / Profile preview
Human Papillomavirus Type 16 L2 Protein (HPV16 L2)
- Target
- HPV16 L2
- Molecular classification
- Viral structural protein, Capsid protein
01
Overview
The L2 protein is the minor capsid protein of Human papillomavirus type 16 (HPV16), a high-risk HPV genotype associated with several human cancers, including cervical cancer. L2 plays multiple critical roles in both virus assembly and infection, including capsid assembly, infectious entry, and nuclear import of viral DNA. It is a target for broad-spectrum vaccine development due to its cross-neutralizing epitopes.
- Other names
- HPV16 minor capsid protein L2
02
Mechanism of action
Neutralization of viral infectivity (through antibody binding)
03
Biological functions
Virion assemblyGenome packagingMediates infectious entryNuclear import of viral DNACell surface interaction
04
Disease associations
CancerInfection
05
Safety considerations
Potential for off-target effects if targeting host cell interactions
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