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Target intelligence / Profile preview
Human Papillomavirus Type 16 Major Capsid Protein L1 (HPV16 L1)
- Target
- HPV16 L1
- Molecular classification
- Structural Protein, Capsid Protein
01
Overview
The major capsid protein L1 of human papillomavirus type 16 (HPV16) is the principal structural protein forming the outer shell (capsid) of the virus. It plays a critical role in viral assembly, infectivity, and immunogenicity. L1 self-assembles into virus-like particles (VLPs), even when expressed recombinantly, and these VLPs form the basis for licensed HPV vaccines. Neutralizing antibodies generated against conformational epitopes on assembled pentamers can block infection effectively.
- Other names
- HPV16 L1 Major Capsid ProteinL1 proteinHPV16 capsid protein
02
Mechanism of action
Vaccination leading to neutralizing antibody production against conformational epitopes, preventing viral entry and infection.
03
Biological functions
Capsid FormationGenome EncapsulationHost Cell EntryImmunogenicityViral Assembly
04
Disease associations
CancerInfection
05
Interacting drugs
Gardasil®
1 more in the full profile.
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