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Target intelligence / Profile preview
Human Papillomavirus Type 16 Oncoprotein E6 (None)
- Target
- None
- Molecular classification
- Oncoprotein, Viral protein
01
Overview
The E6 protein is an oncoprotein encoded by the high-risk human papillomavirus type 16 (HPV16). It promotes cellular immortalization and plays a central role in cervical carcinogenesis and other HPV-associated malignancies by targeting key tumor suppressors like p53 and regulators such as hTERT. It contains two zinc finger domains and a C-terminal PDZ-binding motif.
- Other names
- HPV16 E6E6 protein16E6
02
Mechanism of action
Promotes p53 degradation via ubiquitin-dependent proteasomal pathway and E6AP recruitment; interacts with CBP/p300 to repress transcription; activates telomerase; disrupts cell polarity via PDZ domain interactions; enhances translation initiation complex assembly.
03
Biological functions
p53 degradationTranscriptional repressionTelomerase activationCell immortalizationDisruption of cell polarityEnhancement of protein synthesis
04
Disease associations
CancerCervical cancerAnogenital cancersHead and neck tumorsHPV-associated malignancies
05
Safety considerations
Targeting viral oncoproteins can have off-target effects on host cellular processes.Development of resistance to therapies targeting E6.
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