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Target intelligence / Profile preview
Human Papillomavirus Type 16 Oncoprotein E7 (HPV16 E7)
- Target
- HPV16 E7
- Molecular classification
- Oncoprotein, Viral protein
01
Overview
The Human papillomavirus type 16 (HPV16) oncoprotein E7 is a multifunctional viral protein that plays a central role in the HPV life cycle and in the development of HPV-associated cancers, particularly cervical cancer. It drives quiescent cells into the cell cycle by stimulating progression from G1 to S phase, facilitating viral genome replication. E7 binds to retinoblastoma tumor suppressor protein (pRB), as well as related pocket proteins p107 and p130, leading to their degradation. It also interacts with cullin 2 ubiquitin ligase complex contributing to pRB degradation and interacts with additional targets such as histone deacetylases and the large retinoblastoma-associated factor p600.
- Other names
- E7 oncoproteinHPV16 E7 oncoprotein
02
Mechanism of action
Not applicable, but target of therapeutics
03
Biological functions
Cell cycle deregulationpRB degradationTranscriptional activationCellular transformationStimulation of S-phase entry
04
Disease associations
CancerCervical cancerHPV infection
05
Safety considerations
Targeting E7 without affecting normal cellular processesPotential for off-target effects due to interactions with cellular proteins
06
Biomarkers
E7 protein expression levels as a marker for HPV infection and cancer progression
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