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Target intelligence / Profile preview
Human Papillomavirus Type 18 E6 Protein
- Molecular classification
- Oncoprotein, Viral protein, Transcription factor regulator, E3 ubiquitin ligase recruiter
01
Overview
The E6 protein is an oncogenic protein encoded by the human papillomavirus type 18 (HPV-18) genome. It plays a central role in HPV-induced cellular transformation and is directly implicated in the development of cervical cancer and other HPV-related malignancies. E6 acts primarily by degrading the tumor suppressor p53, activating telomerase, and modulating the immune response. It interacts with host cell proteins, including E6AP, to achieve these functions.
02
Mechanism of action
Recruits E6AP ubiquitin ligase to degrade p53; activates hTERT to increase telomerase activity; inhibits interferon signaling.
03
Biological functions
p53 degradationTelomerase activationImmune modulationCellular transformationViral DNA amplificationInhibition of apoptosis
04
Disease associations
Cervical cancerHPV-related malignanciesInfection
05
Safety considerations
Specificity of inhibitors (avoiding off-target effects)Potential for drug resistanceDelivery challenges (targeting viral proteins within infected cells)
06
Biomarkers
E6 mRNA levels (for HPV infection and cancer risk assessment)p16INK4a expression (as a surrogate marker for E6/E7 activity)
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