Human papillomavirus type 18 early protein 7 messenger RNA (HPV18 E7 mRNA)

HPV18 E7 mRNA is a viral transcript produced by Human Papillomavirus type 18, a high-risk genotype primarily associated with cervical and oropharyngeal cancers (Source: NIH). This messenger RNA encodes the E7 oncoprotein, a potent driver of malignancy that facilitates the degradation of the host's retinoblastoma protein (pRb), leading to cell cycle checkpoint bypass and genomic instability (Source: UniProt). The persistent expression of HPV18 E7 mRNA is a hallmark of HPV-integrated cancer cells, making it an ideal target for precision therapies (Source: NIH). Therapeutic approaches include the use of small interfering RNAs (siRNAs) and antisense oligonucleotides to induce mRNA degradation, as well as CRISPR-based systems for transcript silencing (Source: NIH). Additionally, mRNA-based therapeutic vaccines utilize modified E7 sequences to prime the immune system to recognize and eliminate cells expressing this viral target (Source: ASM).

Other names

HPV18 E7 transcriptHuman papillomavirus 18 E7 mRNAHPV-18 E7 mRNAE7 mRNA of HPV18

Targeted degradation of viral transcripts via RNA interference (RNAi) or antisense oligonucleotides, and the use of synthetic mRNA to encode E7 antigens for therapeutic vaccination to stimulate cytotoxic T-lymphocyte responses (Source: NIH).