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Target intelligence / Profile preview
Human Papillomavirus Type 18 L1 Protein (None)
- Target
- None
- Molecular classification
- Viral structural protein, Capsid protein, Surface antigen
01
Overview
The Human papillomavirus type 18 (HPV18) L1 protein is the major capsid protein of HPV18, a high-risk virus associated with cervical and other anogenital cancers. The L1 protein forms the structural basis of the viral capsid and plays a critical role in virus assembly, infectivity, and immunogenicity. It is the primary target of neutralizing antibodies and the basis for prophylactic HPV vaccines.
- Other names
- Major capsid protein L1HPV-18 Shell ProteinHPV-18 Capsid ProteinHPV-18 Coat ProteinHPV-18 Structural ProteinHPV-18 Viral Capsid Protein L1HPV-18 Outer Capsid ProteinHPV-18 Shell Component L1HPV-18 Capsomer Protein L1HPV Surface Antigen L1
02
Mechanism of action
L1 protein-based vaccines induce neutralizing antibodies that prevent HPV infection by blocking viral entry into host cells.
03
Biological functions
Virion assemblyHost cell attachmentImmune recognitionNeutralization targetVaccine antigen
04
Disease associations
Cervical cancerAnogenital cancersHPV18 infection
05
Interacting drugs
HPV vaccines (e.g., Gardasil, Cervarix)
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