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Target intelligence / Profile preview
Human Papillomavirus Type 18 Major Capsid Protein L1 (HPV18 L1)
- Target
- HPV18 L1
- Molecular classification
- Viral structural protein, Capsid protein
01
Overview
The major capsid protein L1 of human papillomavirus type 18 (HPV18) is the principal structural protein forming the outer capsid of the virus. It is critical for viral assembly, infectivity, and immunogenicity. L1 proteins self-assemble into virus-like particles (VLPs) that form the basis of prophylactic vaccines against HPV18.
- Other names
- HPV-18 Shell ProteinHPV-18 Capsid ProteinHPV-18 Coat ProteinHPV-18 Structural ProteinHPV-18 Viral Capsid Protein L1HPV-18 Outer Capsid ProteinHPV-18 Shell Component L1HPV-18 Capsomer Protein L1HPV-18 Surface Antigen L1
02
Mechanism of action
VLPs generated from L1 protein elicit neutralizing antibodies that prevent viral entry into host cells.
03
Biological functions
Virion assemblyViral genome encapsulationHost cell attachmentInfectivityImmunogenicity
04
Disease associations
InfectionCervical cancer (indirectly, through HPV18 infection)
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