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Target intelligence / Profile preview
Human papillomavirus type 45 major capsid protein L1 (HPV45 L1)
- Target
- HPV45 L1
- Molecular classification
- Viral protein, Capsid protein
01
Overview
The HPV type 45 L1 protein is a structural viral component responsible for forming highly stable virus-like particles that are both necessary for infectious particle assembly and serve as potent antigens in preventive vaccines. Its ability to self-organize without additional factors makes it ideal for recombinant production platforms used globally to prevent cervical cancer associated with high-risk HPVs like type 45.
- Other names
- HPV type 45 major capsid proteinRecombinant human papillomavirus type 45 L1 protein
02
Mechanism of action
Vaccine-induced neutralizing antibodies targeting conformational epitopes on assembled L1 capsids, preventing viral entry and infection
03
Biological functions
Capsid formationVirus assemblyImmunogen
04
Disease associations
InfectionCancer (associated with HPV infection)
05
Safety considerations
Rare allergic reactions to vaccine componentsInjection site reactionsPotential for immune interference with other vaccines (unlikely but possible)
06
Interacting drugs
Gardasil 9 (component)
2 more in the full profile.
07
Biomarkers
L1 antibody titers (correlate with vaccine efficacy)HPV-45 DNA detection (diagnostic)HPV-45 E6/E7 mRNA expression (disease progression)
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