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Target intelligence / Profile preview
Human papillomavirus type 52 major capsid (L1) protein (HPV52 L1)
- Target
- HPV52 L1
- Molecular classification
- Viral structural protein, Capsid protein
01
Overview
The L1 protein is the major capsid protein of human papillomavirus type 52, a high-risk genotype associated with cervical cancer and other anogenital malignancies. L1 mediates initial attachment and entry of HPV into host cells, stabilizes the viral genome during intracellular trafficking, and is a key component of prophylactic vaccines like Gardasil®9, where it is presented as virus-like particles (VLPs) to induce neutralizing antibodies.
- Other names
- HPV type 52 L1 proteinHPV52 L1 capsid protein
02
Mechanism of action
L1 VLPs induce neutralizing antibodies that prevent virus-cell binding and entry.
03
Biological functions
Virus entryCell surface receptor bindingViral genome stabilizationImmunogenCapsid formation
04
Disease associations
Cervical cancerAnogenital malignanciesHPV infection
05
Interacting drugs
Gardasil®9 (indirectly, via VLP presentation)
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