Human papillomavirus type 58 (HPV58)

Human papillomavirus type 58 is a DNA virus belonging to the Papillomaviridae family. It is classified as a high-risk HPV type due to its association with the development of cervical cancer and precancerous lesions, especially prevalent in East Asia. The virus encodes several early (E) proteins (notably E6 and E7) with oncogenic potential, and late (L) structural proteins (including the L1 major capsid protein). Prophylactic vaccines, such as Gardasil 9, include virus-like particles of HPV58 L1 protein to stimulate immune protection, but the virus itself is not a drug target or receptor in the pharmacological sense[1][2][3][4].\n\nClarification:\n- "Human papillomavirus type 58" refers to an entire viral species, not a specific molecule, receptor, or protein. Thus, it is not considered a conventional therapeutic target like a receptor, enzyme, or transporter, but rather a pathogen[2][3][4].\n- The **L1 capsid protein** of HPV58 is used as an antigen in vaccines such as Gardasil 9, where it acts as an immunogen rather than a drug target[3].\n- Drugs (vaccines) do not target the virus with a receptor-based mechanism, but the immune system is trained to recognize the L1 protein to prevent infection[3].\n- For molecule-specific entries, consider "Human papillomavirus type 58 L1 capsid protein" or "HPV58 E6 protein" as singular molecular targets. This query refers to the entire virus.

Other names

HPV-58HPV type 58Human papillomavirus 58