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Target intelligence / Profile preview
Human Papillomavirus Type 58 Virion (HPV58 virion)
- Target
- HPV58 virion
- Molecular classification
- Virus, Non-enveloped virus
01
Overview
The intact human papillomavirus type 58 (HPV58) virion is a key target for neutralizing antibodies, which prevent infection and disease progression. The virion is a non-enveloped, icosahedral particle composed of L1 and L2 capsid proteins, encapsulating a circular double-stranded DNA genome. Neutralizing antibodies, primarily directed at L1, block viral attachment to host cells. Current vaccines utilize virus-like particles (VLPs) made from L1 to induce protective antibody responses against HPV58 and other HPV types. Persistent HPV58 infection is strongly associated with cervical cancer.
- Other names
- HPV58HPV type 58Human papillomavirus 58
02
Mechanism of action
Neutralization of viral infectivity via antibody-mediated blockade of viral attachment/entry into host cells.
03
Biological functions
Viral infectionViral replicationOncogenesisImmune evasion
04
Disease associations
Cervical cancerCervical intraepithelial neoplasiaHPV infection
05
Safety considerations
Potential for immune escape by viral variantsNeed for long-lasting immunityCoverage of all high-risk HPV types in vaccines
06
Interacting drugs
HPV vaccines (e.g., nonavalent vaccine)
1 more in the full profile.
07
Biomarkers
HPV58 DNA detectionHPV58 E6/E7 mRNA expressionAnti-HPV58 neutralizing antibody titers
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