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Target intelligence / Profile preview
Human Papillomavirus Type L1 Capsid Protein (L1)
- Target
- L1
- Molecular classification
- Structural protein, Capsid protein, Viral protein
01
Overview
The L1 protein is the major capsid protein of human papillomaviruses (HPVs). It self-assembles into virus-like particles (VLPs) that form the basis for current prophylactic HPV vaccines. L1 mediates capsid assembly, genome encapsulation, and host cell attachment. It is a highly immunogenic protein that induces neutralizing antibodies, preventing HPV infection and subsequent development of cervical cancer and other malignancies.
- Other names
- HPV L1 ProteinMajor Capsid Protein L1HPV16 L1HPV18 L1HPV6 L1
02
Mechanism of action
L1-based VLPs induce neutralizing antibodies against HPV, preventing infection.
03
Biological functions
Capsid assemblyGenome encapsulationHost cell attachmentVLP formation
04
Disease associations
InfectionCervical cancerHPV-related malignancies
05
Interacting drugs
Gardasil
1 more in the full profile.
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