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Target intelligence / Profile preview
Human Parainfluenza Virus Type 3 (HPIV-3)
- Target
- HPIV-3
- Molecular classification
- Virus, Paramyxoviridae, RNA virus
01
Overview
Human parainfluenza virus type 3 (HPIV-3) is a single-stranded, negative-sense RNA virus in the Paramyxoviridae family. It is a significant respiratory pathogen, particularly affecting infants and young children, causing bronchiolitis, bronchitis, and pneumonia. Transmission occurs through respiratory droplets or direct contact. There are no licensed vaccines or specific antiviral treatments currently available.
- Other names
- PIV3Human respirovirus 3 infectious diseaseInfection caused by human parainfluenza virus type 3
02
Mechanism of action
Ribavirin and favipiravir show some in vitro efficacy, but there are no licensed antiviral treatments for HPIV-3 infection. Management remains supportive.
03
Biological functions
Viral replicationInfectionHost cell entryRespiratory infection
04
Disease associations
BronchiolitisBronchitisPneumoniaRespiratory disease
05
Safety considerations
Lack of approved vaccines or specific antiviral treatmentsRisk of severe respiratory illness, especially in infants, young children, the elderly, and immunocompromised individuals
06
Interacting drugs
Ribavirin
2 more in the full profile.
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