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Target intelligence / Profile preview
Human pluripotency-associated transcript 5 (HPAT5)
- Target
- HPAT5
- Molecular classification
- Other (long noncoding RNA), lincRNA (long intergenic noncoding RNA)
01
Overview
Human pluripotency-associated transcript 5 (HPAT5) is a primate-specific long noncoding RNA that is highly expressed in human embryonic stem cells and is required for the maintenance of pluripotency and proper development of preimplantation embryos. HPAT5 acts through post-transcriptional mechanisms, most notably by binding and sequestering mature let-7 microRNAs—this interaction attenuates let-7 activity and thereby helps preserve stem cell identity and delay differentiation. Loss of HPAT5 leads to increased let-7 levels, which accelerates stem cell differentiation. HPAT5 can function as a biomarker for pluripotency but is not a conventional protein target for drugs[2][3].
- Other names
- HPAT5LOC102725048
02
Mechanism of action
Not applicable, as HPAT5 is not a recognized drug target and no drugs modulate its activity.
03
Biological functions
Regulation of pluripotencyModulation of stem cell differentiationPost-transcriptional regulation of gene expression
04
Disease associations
Other (no direct evidence for a disease role such as cancer or inflammation; primary function is in early embryonic development and stem cell maintenance)
05
Safety considerations
None documented, as HPAT5 is not targeted therapeutically and no interventions against HPAT5 have been tested in humans.
06
Biomarkers
Potential marker for pluripotent stem cells (HPAT5 presence indicates pluripotency in human stem cells)
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