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Target intelligence / Profile preview
Poliovirus receptor (PVR (CD155))
- Target
- PVR (CD155)
- Molecular classification
- Receptor, Cell adhesion molecule, Immunomodulatory protein
01
Overview
The Poliovirus receptor (PVR, CD155) is a cell surface protein belonging to the immunoglobulin superfamily, initially identified as the cellular entry receptor for the human poliovirus. PVR mediates poliovirus attachment and entry into host cells, and alternative splicing generates both soluble and transmembrane isoforms. Beyond its virological role, PVR functions as an important cell adhesion and immunomodulatory molecule, regulating leukocyte migration and checkpoint pathways via interactions with CD226 and TIGIT. It is also implicated in cancer progression and immune evasion, making it both a biomarker and a therapeutic target in oncology
- Other names
- CD155PVRhuman poliovirus receptor
02
Mechanism of action
Viral attachment and entry via receptor binding; One investigational mechanism is oncolytic destruction of cancer cells by engineered poliovirus exploiting PVR overexpression
03
Biological functions
Viral entry mediatorCell adhesionRegulation of immune responseTransendothelial leukocyte migration
04
Disease associations
Infection (poliovirus)Cancer (biomarker and therapeutic target)Immune regulation
05
Safety considerations
Viral tropism can lead to neuroinvasion in vaccine strainsPVR upregulation in tumors may have immunomodulatory effects
06
Interacting drugs
Live attenuated poliovirus (e.g., Sabin vaccine strains)
2 more in the full profile.
07
Biomarkers
PVR overexpression in cancers (biomarker for patient selection and prognosis)
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