Human proislet peptide (HIP)

Human proislet peptide (HIP) is a regulatory peptide shown to promote the differentiation of human fetal pancreatic progenitor cells into functional β cells by inducing the expression of key proislet transcription factors. HIP exerts its effect through the AKT/FOXO/menin pathway, leading to epigenetic modifications that favor islet cell maturation. Experimental studies indicate that HIP treatment increases insulin content, facilitates β-cell functional maturation, and can normalize blood glucose in diabetic animal models, highlighting its potential as a therapeutic candidate for diabetes cell therapy and regenerative medicine[8].

Other names

HIPProislet peptideHuman proislet peptide

Promotes pancreatic β-cell differentiation by upregulating expression of pro-islet transcription factors Signals via the AKT/FOXO/menin axis to epigenetically regulate islet cell gene expression[8]