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Target intelligence / Profile preview
Human Rotavirus Live Attenuated Virus
- Molecular classification
- Virus, Live Attenuated Virus, Reoviridae, Rotavirus
01
Overview
The human rotavirus live attenuated virus is a weakened form of the wild-type human rotavirus, used as an oral vaccine to prevent severe gastroenteritis in infants and young children. It replicates locally in the small intestine, stimulating mucosal and systemic immunity. Key antigens are VP7 (G-protein) and VP4 (P-protein) which induce neutralizing antibodies. Vaccines include Rotarix (monovalent, human strain) and RotaTeq (pentavalent, bovine/human reassortant).
- Other names
- RotarixRotaTeqRIX4414Live attenuated rotavirus vaccine
02
Mechanism of action
Stimulates mucosal and systemic immunity through limited replication in the small intestine, leading to production of neutralizing antibodies (IgA and IgG) against viral proteins, particularly VP7 and VP4.
03
Biological functions
Induction of immune responseViral replication (attenuated)Antigen presentationStimulation of mucosal immunity
04
Disease associations
Prevention of Rotavirus GastroenteritisInfection
05
Safety considerations
Intussusception (rare)Viral shedding post-vaccination
06
Biomarkers
Anti-rotavirus IgA antibody seroconversion
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