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Target intelligence / Profile preview
Human serum albumin (HSA)
- Target
- HSA
- Molecular classification
- Protein, Serum albumin family
01
Overview
Human serum albumin (HSA) is the most abundant protein in human blood plasma, constituting about half of the total serum protein content. It plays a critical role in maintaining oncotic pressure, regulating blood pH, and transporting a wide variety of endogenous and exogenous substances including hormones, fatty acids, bilirubin, thyroxine (T4), cations (such as Ca²⁺, Na⁺, K⁺), and many pharmaceuticals.
02
Mechanism of action
Serves as a carrier for various ligands, influencing their distribution and bioavailability.
03
Biological functions
Maintains oncotic pressureBuffers blood pHTransports fatty acidsTransports hormonesTransports bilirubinTransports metal ionsTransports pharmaceuticalsTransports vitaminsTransports growth factors
04
Disease associations
HypoalbuminemiaShock states
05
Safety considerations
Low immunogenicity
06
Interacting drugs
Fatty acids
5 more in the full profile.
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