Human serum albumin N-terminal 12-mer peptide (wAlb12)

The wAlb12 peptide is a synthetic 12-amino acid sequence derived from the N-terminal region of human serum albumin (HSA). It is characterized by the presence of an amino-terminal Cu(II)- and Ni(II)-binding (ATCUN) motif, which allows it to bind divalent metal ions like cobalt, copper, and nickel with high affinity and specificity [1, 5]. While not a traditional therapeutic target such as a receptor or enzyme, wAlb12 has been developed as a biocompatible peptide-based chelate for radiopharmaceuticals. It is primarily used to carry radioactive isotopes, such as Cobalt-57, to facilitate targeted cancer diagnosis and therapy [4, 6]. Research has demonstrated that the peptide is non-toxic to various mammalian cell lines and exhibits enhanced stability when complexed with metal ions, making it a promising tool for the development of novel diagnostic and therapeutic agents [1, 6].

Other names

wAlb12 peptideHSA N-terminal peptideCobalt-binding peptide chelateATCUN-motif peptide

Acts as a high-affinity peptide-based chelate that utilizes the amino-terminal Cu(II)- and Ni(II)-binding (ATCUN) motif to coordinate radioactive isotopes, such as Cobalt-57, for targeted delivery in cancer diagnosis and therapy [1, 6].