Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Human Sodium Iodide Symporter (NIS)
- Target
- NIS
- Molecular classification
- Transporter, Membrane protein, Glycoprotein
01
Overview
The human sodium iodide symporter (NIS) is a transmembrane glycoprotein responsible for the active transport of iodide into cells, primarily thyroid follicular cells. It plays a crucial role in thyroid hormone biosynthesis and is a key target for radioiodine-based diagnostics and therapeutics, particularly in thyroid cancer. NIS expression is also observed in other tissues, including salivary glands, gastric mucosa, mammary glands, and some tumors, offering potential diagnostic and therapeutic opportunities beyond thyroid diseases.
- Other names
- SLC5A5sodium/iodide cotransporterTDH1solute carrier family 5 member 5
02
Mechanism of action
Active transport of iodide ions into cells, driven by the sodium gradient, enabling radioiodine uptake for imaging and therapy. Competitively inhibited by anions such as perchlorate and thiocyanate.
03
Biological functions
Iodide transportThyroid hormone synthesisSodium-dependent transport
04
Disease associations
Congenital hypothyroidismThyroid cancerBreast cancer
05
Safety considerations
Off-target effects of radioiodine therapyDevelopment of radioiodine resistance in tumorsImmunogenicity of ectopic NIS expression
06
Interacting drugs
Radioiodine isotopes (^131I, ^123I)
1 more in the full profile.
07
Biomarkers
NIS expression levels in thyroid cancerNIS expression in breast cancer
Beyond the preview
Go deeper on Human Sodium Iodide Symporter (NIS).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Human Sodium Iodide Symporter (NIS).