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Human Telomerase Reverse Transcriptase Promoter-Driven Viral Replication
- Molecular classification
- DNA Promoter, Regulatory Sequence
01
Overview
The human telomerase reverse transcriptase (hTERT) promoter is a regulatory DNA sequence that controls the expression of the hTERT gene. In cancer therapy, it is exploited to drive tumor-selective replication of oncolytic viruses or expression of therapeutic genes due to its high activity in cancer cells and low/absent activity in most normal somatic cells. Activating mutations within this promoter are also frequently observed across a range of cancers.
- Other names
- hTERT promoterTERT promoter
02
Mechanism of action
N/A (promoter sequence itself does not have a mechanism of action)
03
Biological functions
Transcriptional regulationTumor-selective gene expressionControl of viral replication
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target viral replication if promoter specificity is not absoluteRisk of insertional mutagenesis if viral vectors are usedImmune response to viral vectors
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