Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Human Tissue Kallikrein (KLK)
- Target
- KLK
- Molecular classification
- Enzyme, Serine Protease
01
Overview
Human tissue kallikreins are a family of fifteen closely related serine proteases encoded by genes on chromosome 19q13.4. They play diverse roles in physiological processes such as blood pressure regulation, semen liquefaction, skin shedding, and cell signaling. These enzymes are involved in various diseases and are targets for drug development, particularly in cancer and cardiovascular conditions. Their activity is significant in the kallikrein-kinin system, which influences inflammation and other physiological responses.
- Other names
- Tissue KallikreinHuman Kallikrein-Related Peptidases (KLKs)
02
Mechanism of action
Inhibition of serine protease activity to prevent bradykinin release and subsequent inflammation or edema
03
Biological functions
Signal transductionBlood pressure regulationSemen liquefactionSkin desquamationCell signalingInnate immunityNeuronal plasticity
04
Disease associations
Cancer (e.g., prostate cancer)InflammationCardiovascular diseaseNeurodegenerative disease (e.g., Alzheimer's, Parkinson's)
05
Safety considerations
Hypotensionpotential for affecting blood pressure regulationtherapeutic challenges include managing side effects in drug development
06
Interacting drugs
Ecallantide
2 more in the full profile.
07
Biomarkers
Prostate-specific antigen (PSA) is a member of the kallikrein family and used for prostate cancer diagnosisother KLKs are potential biomarkers for various conditions
Beyond the preview
Go deeper on Human Tissue Kallikrein (KLK).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Human Tissue Kallikrein (KLK).