Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Huntingtin associated protein 1 (HAP1)
- Target
- HAP1
- Molecular classification
- Adaptor protein, Intracellular trafficking protein
01
Overview
Huntingtin-associated protein 1 (HAP1) is a neuronal protein involved primarily in intracellular vesicular trafficking but also participates broadly in signal transduction pathways that maintain synaptic function/neural health. Its dysfunction may underlie selective vulnerability seen in neurodegenerative disorders like Huntington’s disease. It acts as an adaptor linking vesicles/organelle cargoes to transport machinery and regulates endocytosis, recycling, stability, and degradation prevention for several membrane receptors. Through interactions with transcription factors and kinases it influences gene expression pathways relevant for neuronal differentiation/survival.
- Other names
- HAP2Neuroan 1
02
Mechanism of action
N/A
03
Biological functions
Intracellular traffickingVesicle/organelle transportMembrane receptor regulationCalcium homeostasisNeurite outgrowthSynaptic transmission/plasticityNeurotrophic supportSignal transductionTranscriptional regulation
04
Disease associations
Huntington's diseaseNeurodegenerative diseasePotential tumor suppressor in gastric cancer
05
Safety considerations
Dysfunction leads to impaired intracellular trafficking and neurodegeneration
Beyond the preview
Go deeper on Huntingtin associated protein 1 (HAP1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Huntingtin associated protein 1 (HAP1).