Hyaluronan-binding protein (HABP)

Hyaluronan-binding proteins, or hyaladherins, are a class of molecules that bind selectively to hyaluronic acid, a major glycosaminoglycan of the extracellular matrix. They perform key structural and signaling functions, mediating cell adhesion, migration, and communication. Prominent examples include CD44, RHAMM, LYVE-1, Stabilin-2 (HARE), versican, and aggrecan. These proteins regulate diverse biological processes, including tissue hydration, inflammation, tumor metastasis, and tissue repair. Aberrant HA binding and turnover are implicated in diseases such as cancer, fibrosis, arthritis, and neurodegenerative disorders.

Other names

HyaladherinHyaluronan-binding proteinHA-binding proteinHABPLink module proteins (includes CD44, RHAMM, LYVE-1, HARE/Stabilin-2, versican, aggrecan, TSG-6, etc.)

Mechanisms include enzymatic degradation of hyaluronic acid (e.g., hyaluronidase), blocking HA-receptor interactions (e.g., anti-CD44 antibodies), modulation of ECM structure via inhibition or enhancement of HA-protein binding, and disrupting HA accumulation to enhance drug penetration in tumors.