Hyaluronan-binding protein family receptor

The “Hyaluronan-binding protein family receptors” refers to a collection of cell surface proteins that recognize and bind hyaluronan, a major extracellular matrix glycosaminoglycan involved in tissue structure, cell signaling, and inflammation. The most well-studied human hyaluronan receptors are **CD44** and **RHAMM (HMMR/CD168)**, both of which mediate diverse functions such as cellular adhesion, migration, proliferation, and inflammation[1][2][3]. **Stabilin-2 (HARE)** is another significant receptor, mainly involved in the clearance of hyaluronan and related molecules from the circulation[2]. These receptors play essential roles in normal physiology as well as in pathologies like cancer, chronic inflammation, and tissue remodeling. Therapeutic targeting of hyaluronan-receptor pathways is under investigation for oncology and inflammatory diseases, largely focusing on CD44. The term “Hyaluronan-binding protein family receptors” is not itself a canonical molecule but rather a functional grouping; when detailed drug or biology information is required, it is appropriate to specify the individual receptor (e.g., CD44, RHAMM, Stabilin-2)[1][2]. *Note*: The submitted target is overly broad and not a canonical molecule or gene—it represents a heterogeneous family rather than a discrete entity. For structured databases, it is preferable to use individual receptor names with specific genes/proteins.

Other names

CD44RHAMM (Receptor for Hyaluronan-Mediated Motility, also known as HMMR or CD168)Stabilin-2 (also known as HARE)hyaladherins

Blockade of ligand binding (e.g., anti-CD44 antibodies prevent hyaluronan interaction); Inhibition of downstream signaling (reduces pro-tumorigenic or pro-inflammatory pathways); Alteration of cell adhesion/migration properties