Hyaluronan mediated motility receptor (RHAMM)

The Hyaluronan mediated motility receptor (RHAMM; also known as HMMR or IHABP) is a cell surface and intracellular protein that binds to hyaluronan—a major component of the extracellular matrix. It plays a critical role in regulating cell motility, migration, and proliferation. When hyaluronan binds to RHAMM, it triggers phosphorylation events involving proteins such as PTK2/FAK1 and can activate the ERK signaling pathway. This receptor is implicated in processes like inflammation, wound healing, tissue remodeling, and especially cancer progression by promoting cellular transformation and metastasis formation. Multiple isoforms exist due to alternative splicing; some are associated with aggressive tumor phenotypes when localized in the nucleus or on the cell surface. The primary endogenous ligand for this target is hyaluronic acid itself[4][1].

Other names

RHAMMHMMRIHABPIntracellular hyaluronic acid-binding proteinReceptor for hyaluronan-mediated motility

Binding of hyaluronan to RHAMM activates intracellular signaling pathways such as phosphorylation of PTK2/FAK1 and ERK pathway, influencing cell migration and proliferation