Hyaluronic acid–L-arginine complex (HA-Arg)

The hyaluronic acid–L-arginine non-covalent complex within a hydrogel is a biomaterial system formed by the electrostatic and hydrogen-bonding interactions between the anionic carboxyl groups of hyaluronic acid and the cationic guanidino groups of L-arginine [1]. Hyaluronic acid is a naturally occurring glycosaminoglycan that provides structural integrity to the extracellular matrix and regulates cell adhesion and mobility [2]. L-arginine is a semi-essential amino acid that serves as the primary substrate for nitric oxide (NO) production, which plays a vital role in vasodilation, immune response, and tissue repair [3]. This complex is not a traditional therapeutic target such as a receptor or enzyme; rather, it is a functional delivery platform designed to stabilize hyaluronic acid and provide a sustained release of L-arginine or other encapsulated therapeutic agents [4]. In clinical applications, these hydrogels are used to promote wound healing, manage osteoarthritis, and serve as injectable fillers in aesthetic medicine [5]. The complex enhances the biological activity of the individual components, facilitating improved angiogenesis and reduced inflammation at the site of administration [6].

Other names

Hyaluronan-L-arginine complexHA-arginine hydrogelArginine-stabilized hyaluronic acidHyaluronic acid-arginine non-covalent complex

Provides a biocompatible scaffold for tissue regeneration and acts as a reservoir for the sustained release of therapeutic agents and L-arginine for nitric oxide synthesis.