Hyaluronic acid receptor (CD44) (CD44)

Hyaluronic acid-based products for vaginal use target CD44 (hyaluronic acid receptor) on the vaginal mucosa, facilitating moisture retention through formation of a hydrated extracellular matrix. The products adhere to the mucosal surface (mucoadhesion), allowing sustained local hydration, enhanced mucosal repair, and tissue remodeling. Expression of CD44 and aquaporin 3 (AQP3) are critical for optimizing hydration and cellular water transport. These therapies are clinically used for conditions associated with vaginal dryness, especially during menopause or after childbirth, and have a high safety profile. Alternative treatments include formulations with additional active components (e.g., vitamins, antioxidants, PRP) to further support vaginal tissue health and repair.

Other names

CD44hyaluronan receptorcell surface glycoprotein CD44

Formation of extracellular matrix by retention of water via hyaluronic acid. Mucoadhesion (adherence to vaginal mucosa via CD44). Induction of AQP3 (aquaporin 3) for direct water transport into epithelium. Promotion of cell proliferation and tissue repair (VEGF-driven angiogenesis).