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Target intelligence / Profile preview
Hyaluronic Acid Synthesis (HAS)
- Target
- HAS
- Molecular classification
- Enzyme complex, Metabolic pathway
01
Overview
Hyaluronic acid (HA) synthesis is the process of producing the linear glycosaminoglycan HA, a major component of the extracellular matrix. It involves the coordinated action of multiple enzymes, primarily hyaluronan synthases (HAS1, HAS2, HAS3), which polymerize UDP-glucuronic acid (UDP-GlcUA) and UDP-N-acetylglucosamine (UDP-GlcNAc) into HA. These precursors are derived from glucose through complex metabolic pathways. HA synthesis is crucial for maintaining tissue hydration, elasticity, and facilitating cell migration and proliferation. It is also a therapeutic target for various conditions, including cancer and inflammatory diseases.
- Other names
- Hyaluronan SynthesisHA Synthesis
02
Mechanism of action
Inhibition of precursor availability or enzyme function
03
Biological functions
Extracellular matrix synthesisTissue hydrationOsmotic pressure regulationCell migration facilitationCell proliferation regulation
04
Disease associations
CancerInflammationWound healingSkin agingOther
05
Safety considerations
Modulation may affect tissue integrity and wound healing.Potential for off-target effects on related glycosaminoglycan synthesis pathways.
06
Interacting drugs
4-methylumbelliferone
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