Hyaluronidase

Hyaluronidase refers to a family of enzymes that catalyze the degradation of hyaluronic acid, a major component of the extracellular matrix. By breaking down hyaluronic acid, these enzymes reduce the viscosity of extracellular fluids and increase tissue permeability. Different isoforms (HYAL1-5) exist with distinct tissue distributions and functions, including roles in drug absorption, fertilization, and cancer progression. Marketed forms include recombinant human hyaluronidase used for improving drug dispersion during injections or managing complications from dermal fillers.

Other names

HYAL1HYAL2HYAL3HYAL4HYAL5SPAM1PH-20HYALP1 (pseudogene)

Hydrolysis of β(1→4) glycosidic bonds between N-acetylglucosamine and glucuronic acid residues in hyaluronic acid, reducing its molecular size and viscosity.