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Hyaluronidase (human recombinant) (None)

Target: None
Molecular classification: Enzyme, Glycosidase, Hyaluronidase

Overview

Hyaluronidase (human recombinant) is a purified, recombinant form of the human enzyme hyaluronidase, produced using genetically engineered Chinese Hamster Ovary (CHO) cells that express a soluble fragment of human hyaluronidase PH20. It catalyzes the hydrolysis of hyaluronic acid, a major component of the extracellular matrix, increasing tissue permeability and facilitating the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents.

Other names: Vorhyaluronidase alfa36-482-Hyaluronoglucosaminidase PH20 (human)CUMULASERecombinant Human Hyaluronidase

Mechanism of action

Hydrolyzes hyaluronic acid, reducing viscosity and increasing tissue permeability, thereby enhancing the absorption and dispersion of co-administered substances.

Biological functions

Hydrolysis of hyaluronic acidRegulation of tissue permeabilityExtracellular matrix remodeling

Disease associations

Mucopolysaccharidosis type IXCancer (context-dependent)Other

Safety considerations

Potential immunogenicityRare allergic reactionsExacerbation of pre-existing conditions (case-by-case basis)Potential for increased tumor spread (context-dependent)

Interacting drugs

Hylenex

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