Hyccin PI4KA lipid kinase complex subunit 2 (HYCC2)

Hyccin PI4KA lipid kinase complex subunit 2 (HYCC2) is a protein component of a multimeric lipid kinase complex at the plasma membrane, made up of the catalytic subunit PI4KIIIα (PI4KA) and regulatory subunits, including TTC7 and HYCC2 (also known as FAM126B)[4][5][7]. HYCC2 plays a critical role in stabilizing the PI4KIIIα complex and localizing it to the plasma membrane, where the complex catalyzes the formation of phosphatidylinositol-4-phosphate (PI4P), a lipid essential for maintaining membrane identity, cellular signaling, exo- and endocytosis, and cytoskeletal dynamics[4][5][6]. Defects in HYCC2 are associated with rare forms of hypomyelinating leukoencephalopathy, as well as gastrointestinal and immunological defects[5][6]. Although HYCC2 is not a direct drug target, it is a key structural and regulatory component in the PI4KA lipid kinase complex, whose catalytic subunit is under investigation for drug discovery, particularly with kinase inhibitors[4].

Other names

FAM126BMGC39518Family with sequence similarity 126 member BProtein FAM126Bhyccin 2

Inhibitors act by blocking the catalytic activity of PI4KA lipid kinase within the complex, disrupting phosphoinositide signaling at the plasma membrane[4].