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The term **"hydrogen nuclei"** refers to the atomic nucleus of hydrogen, which consists of a single proton in its most common isotope (^1H), or may include one or two neutrons in the isotopes deuterium (^2H) and tritium (^3H). In chemistry and biology, hydrogen atoms are essential components of water and organic molecules. In nuclear physics, "hydrogen nuclei" are important for processes such as nuclear fusion—where they combine under extreme conditions to form helium and release energy, as occurs in stars like the Sun[8]. However, "hydrogen nuclei" do not refer to any receptor, enzyme, transporter protein, or other conventional biological macromolecule that would be considered a therapeutic target. They do not have structure–function relationships typical for drug targets nor do they participate directly in signal transduction or disease pathways. Thus, listing "hydrogen nuclei" as a molecular/receptor target is incorrect within biomedical research conventions. **Note:** If you intended “Hydrogenase” (an enzyme that catalyzes reactions involving molecular hydrogen), see [1] for details on its classes ([Fe]-Hydrogenase etc.), but “Hydrogen nuclei” itself is not an actionable biological/therapeutic target.
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