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Target intelligence / Profile preview
Hydrogen-potassium ATPase (H⁺/K⁺-ATPase)
- Target
- H⁺/K⁺-ATPase
- Molecular classification
- P-type ATPase, P2-type ATPase, Enzyme, Transporter
01
Overview
Hydrogen-potassium ATPase plays a central role in digestive physiology through its unique ability to generate highly acidic conditions within the stomach while maintaining cellular ionic balance. Its structure-function relationship underpins both normal gastrointestinal function and therapeutic intervention strategies targeting excessive or pathological acid production.
- Other names
- Gastric proton pumpProton pump
02
Mechanism of action
Covalent binding to cysteine residues of H⁺/K⁺-ATPase, inhibiting its activity and reducing gastric acid secretion.
03
Biological functions
Gastric acid secretionPotassium reabsorptionAcid-base balanceDigestionDefense against ingested pathogens
04
Disease associations
Gastroesophageal reflux disease (GERD)Peptic ulcersZollinger-Ellison syndrome
05
Interacting drugs
Proton pump inhibitors (PPIs)
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