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Target intelligence / Profile preview
Hydrogen Sulfide Donor Effect
- Molecular classification
- Other
01
Overview
Hydrogen sulfide donor effect refers broadly to the biological outcomes resulting from controlled exogenous administration/release of hydrogen sulfide using chemical donor molecules—a rapidly expanding area with significant translational promise across multiple medical fields.
- Other names
- H2S donorHydrogen sulfide releasing compounds
02
Mechanism of action
H2S donors release hydrogen sulfide (H2S), which modulates various signaling pathways, including ion channel regulation, protein persulfidation, Nrf2 activation, PI3K/Akt/MAPK/Wnt/NF-κB pathway modulation, soluble guanylyl cyclase (sGC) interaction, and K⁺ channel opening.
03
Biological functions
Cardiovascular protectionRegulation of blood pressureRenal function regulationAnti-inflammatory responsesOxidative stress modulationAngiogenesis promotionBone metabolism regulationCancer cell apoptosis induction
04
Disease associations
Cardiovascular diseaseKidney disease/hypertensionInflammationBony disordersCancer
05
Safety considerations
Dose-dependent effects (low vs. high concentrations)Off-target effectsPotential for uncontrolled H2S release
06
Interacting drugs
NaHS
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