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Hydroxyacid oxidase 1 (HAO1)
- Target
- HAO1
- Molecular classification
- Enzyme, Alpha-hydroxy acid oxidase, FMN-dependent enzyme
01
Overview
Hydroxyacid oxidase 1 (HAO1), also known as glycolate oxidase, is an FMN-dependent enzyme primarily involved in the oxidation of glycolate to glyoxylate and further to oxalate, with the concomitant reduction of oxygen to hydrogen peroxide. It plays a central role in peroxisomal metabolism and is highly expressed in the liver and pancreas. HAO1 is clinically relevant due to its involvement in hyperoxaluria and ethylene glycol poisoning.
- Other names
- GOXGOX1HAOX1Glycolate oxidase
02
Biological functions
Oxidation of glycolate to glyoxylateOxidation of glyoxylate to oxalateHydrogen peroxide productionPeroxisomal metabolism of 2-hydroxy acids
03
Disease associations
HyperoxaluriaKidney stone formationEthylene glycol poisoning toxicity
04
Safety considerations
Excessive hydrogen peroxide production
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