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Target intelligence / Profile preview
Hydroxyapatite Crystal (HAP)
- Target
- HAP
- Molecular classification
- Mineral, Inorganic material
01
Overview
Hydroxyapatite (HAP), with the chemical formula Ca₁₀(PO₄)₆(OH)₂, is a naturally occurring mineral form of calcium apatite. It is the principal inorganic component of bone and dental enamel. The dissolution of hydroxyapatite crystals is a key process in physiological and pathological conditions, such as bone remodeling, dental caries, and certain tumor microenvironments. Targeting HAP dissolution is relevant in dental health (caries prevention), bone diseases (osteoporosis), and cancer therapy (targeting ectopic tumor-associated HAP).
- Other names
- Calcium phosphateBone mineralDental enamel
02
Mechanism of action
Modulation of crystal dissolution rate through pH changes, ion substitution, or barrier formation.
03
Biological functions
Structural supportCalcium reservoirPhosphate reservoir
04
Disease associations
Dental cariesOsteoporosisTumor microenvironment
05
Safety considerations
Excessive dissolution leading to bone lossEctopic deposition in soft tissues
06
Interacting drugs
Fluoride
1 more in the full profile.
07
Biomarkers
Calcium levelsPhosphate levels
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