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Target intelligence / Profile preview
Hydroxycitric Acid (HCA)
- Target
- HCA
- Molecular classification
- Organic Acid, Citric Acid Derivative
01
Overview
Hydroxycitric acid (HCA) is a naturally occurring organic compound found in the rinds of fruits from the Garcinia species. It is known for its potential effects on weight management and metabolism by inhibiting ATP citrate lyase, an enzyme involved in fatty acid synthesis. While animal studies suggest benefits, human clinical trials have yielded mixed results regarding efficacy for weight loss and other metabolic effects.
- Other names
- Garcinia Acid(-)-Hydroxycitric Acid(1S,2S)-1,2-dihydroxypropane-1,2,3-tricarboxylic acid
02
Mechanism of action
Inhibits ATP citrate lyase, reducing the availability of acetyl-CoA needed for fatty acid and cholesterol biosynthesis. May also inhibit pancreatic alpha-amylase and intestinal alpha-glucosidase.
03
Biological functions
ATP citrate lyase inhibitionPotential reduction of fatty acid synthesisPotential appetite suppressionPotential calcium oxalate crystal dissolution
04
Disease associations
Obesity (potential)Kidney stones (potential)
05
Safety considerations
Gastrointestinal upset (nausea, discomfort)Potential for testicular toxicity at high doses (animal studies)Contraindicated in individuals with colitis or inflammatory bowel disease
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