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Hydroxymethylglutaryl-coenzyme A reductase (HMG-CoA reductase)

Target: HMG-CoA reductase
Molecular classification: Enzyme

Overview

Hydroxymethylglutaryl-coenzyme A reductase (HMG-CoA reductase) is a key enzyme in the mevalonate pathway, which is responsible for the biosynthesis of cholesterol and other important isoprenoids. It catalyzes the conversion of HMG-CoA to mevalonic acid, representing the rate-limiting step in cholesterol synthesis. The enzyme's central role in cholesterol biosynthesis makes it a primary target for statins—a class of drugs used to lower blood cholesterol by inhibiting this enzyme's function.

Other names: HMGCR

Mechanism of action

Inhibition of HMG-CoA reductase, reducing cholesterol synthesis

Biological functions

Cholesterol synthesisIsoprenoid synthesisRegulation of mevalonate pathway

Disease associations

Cardiovascular disease

Safety considerations

Muscle toxicity (myopathy)Altered cell signaling pathways

Interacting drugs

Statins

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