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Target intelligence / Profile preview
Hydroxysteroid 11-beta-dehydrogenase 1-like protein (HSD11B1L)
- Target
- HSD11B1L
- Molecular classification
- Enzyme, Short-chain dehydrogenase/reductase (SDR) family
01
Overview
Hydroxysteroid 11-beta-dehydrogenase 1-like protein (HSD11B1L) is an enzyme belonging to the short-chain dehydrogenase/reductase (SDR) superfamily. It catalyzes the interconversion of inactive to active glucocorticoids, resembling the enzymatic function of HSD11B1, which is involved in cortisol and cortisone metabolism. HSD11B1L is mainly present in humans and certain other higher organisms, but is absent in rodent genomes. Mutations in or dysregulation of HSD11B1L may be implicated in cortisone reductase deficiency and possibly other steroid-related disorders. Alternative splicing results in multiple isoforms of the protein. Its status as a therapeutic target is suggested by its role in steroid metabolism, but no drugs are directly identified as targeting HSD11B1L to date
- Other names
- HSD11B1LHSD1LSCDR10SCDR10BSDR26C2HSD311-beta-hydroxysteroid dehydrogenase type 3Hydroxysteroid 11-beta-dehydrogenase 1-like proteinShort chain dehydrogenase/reductase 10Short chain dehydrogenase/reductase family 26C member 2
02
Mechanism of action
Drugs targeting this molecule would likely act by modulating glucocorticoid activation/inactivation, but no specific mechanisms are described for HSD11B1L
03
Biological functions
Catalyzes interconversion of inactive to active glucocorticoids (e.g., cortisone to cortisol)Possible role in steroid hormone metabolism
04
Disease associations
Cortisone reductase deficiencyOther potential roles in steroid-related metabolic and endocrine disorders
05
Safety considerations
Notable safety concerns are not specifically documented; theoretical concerns may relate to effects on steroid hormone balance
06
Interacting drugs
No direct interacting drugs are currently listed in the search results; knowledge of related family members (HSD11B1) suggests potential for interaction with glucocorticoid-modifying agents, but evidence for HSD11B1L itself is lacking
07
Biomarkers
No validated biomarkers for patient selection or efficacy monitoring are reported for HSD11B1L
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