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Hydroxysteroid 17-beta dehydrogenase 1 pseudogene 1 (HSD17B1P1, SDR28C1P1) is a non-functional genomic sequence that shares homology with the *HSD17B1* gene, which encodes the enzyme 17-beta-hydroxysteroid dehydrogenase type 1[5][1]. Pseudogenes do not produce an active protein and are not considered therapeutic targets, biomarkers, or disease-associated entities. The functional *HSD17B1* gene is involved in steroid hormone metabolism, especially conversion between estrone and estradiol, and has relevance as a drug target in estrogen-dependent cancers—however, these properties do not extend to its pseudogene variant[1][3][5].
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