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Target intelligence / Profile preview
Hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13)
- Target
- HSD17B13
- Molecular classification
- Enzyme, Short-chain dehydrogenase/reductase (SDR) superfamily
01
Overview
Hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) is a liver-enriched enzyme belonging to the short-chain dehydrogenase/reductase (SDR) superfamily. It plays a crucial role in hepatic lipid metabolism by catalyzing the oxidation of various lipid substrates, including steroids, eicosanoids, and retinoids. HSD17B13 is primarily localized to lipid droplets within hepatocytes and its expression is significantly upregulated in nonalcoholic fatty liver disease (NAFLD). Loss-of-function variants of HSD17B13 have been shown to protect against hepatic steatosis, fibrosis progression, and chronic liver disease, making it a promising therapeutic target for NAFLD and related conditions. Therapeutic strategies involve inhibitors or RNAi-based therapies aimed at reducing hepatic HSD17B13 expression.
- Other names
- HSD17B13 mRNA
02
Mechanism of action
Inhibition of HSD17B13 to reduce hepatic steatosis and fibrosis.
03
Biological functions
Hepatic lipid metabolismOxidation of steroidsOxidation of eicosanoidsOxidation of retinoids
04
Disease associations
Nonalcoholic fatty liver disease (NAFLD)Chronic liver disease (CLD)Hepatic steatosisFibrosisHepatocellular carcinoma
05
Safety considerations
Potential for off-target effects due to sequence homology with other SDR family members.Long-term effects of HSD17B13 inhibition are not fully understood.
06
Biomarkers
HSD17B13 mRNA expression levels in liver biopsies
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