Hydroxysteroid dehydrogenase 4 pseudogene

The hydroxysteroid dehydrogenase 4 pseudogene (ENSG00000253336) is a nonfunctional genomic sequence related to the family of 17beta-hydroxysteroid dehydrogenases. Unlike the functional enzyme genes in this family (such as HSD17B4, which is involved in steroid and fatty acid metabolism in peroxisomal beta-oxidation), this pseudogene does not encode an active protein. It is retained in the genome as a result of gene duplication or retrotransposition but has lost the ability to produce a functional enzyme. There is no evidence this pseudogene is expressed or involved in disease, drug response, or any biological process relevant to receptor, enzyme, transporter, or therapeutic target functions[1][2][5][4]. Key point: This entry refers to a pseudogene, not a protein-coding gene or functional molecular target. The related functional enzymes (such as HSD17B4) are important in human steroid metabolism and disease, but this pseudogene is not implicated in any recognized molecular pharmacology or biology.

Other names

17beta-hydroxysteroid dehydrogenase pseudogeneLOC392266ENSG00000253336